This model was derived
directly from the circuit board described in Laboratory #1of
Wyttenbach, R.A., Johnson, B.R., Hoy, R.R. (1999). Crawdad:
A CD-ROM Lab Manual for Neurophysiology (Student Version).
Sinauer. It models a cylindrical axon with passive
membrane as a
series of identical compartments, each represented by a high transmembrane resistance
Rm = 1kW,
and each separated from its neighbors by moderate
intracellular longitudinal resistances Ri = 100W
and small extracellular longitudinal resistances Ro=10W.
Recording access to each compartment is provided by a pair of
simple machine screw posts - intracellular (red) and
extracellular (black).
As described in
Crawdad Lab #1 and
Laboratory #8 of the BIO325 manual, this model is used with
a constant DC voltage (supplied by a 9V battery) to study
spatial decay of input signal amplitude with distance, as well
as the differences between intracellular (transmembrane) and
extracellular recording perspectives.
The results of using this model as described in
laboratory #8 are detailed in the Crawdad manual and are available upon request from
brhoades@wesleyancollege.edu . |